The implementation of continuous flowtechnology is critical towards enhancing the application of photochemicalreactions for industrial process development. However, there are significanttime and resource constraints associated with translating discovery scale vial basedbatch reactions to continuous flow scale-up conditions. Herein we report thedevelopment of a droplet microfluidic platform, which enables high-throughputreaction discovery in flow to generate pharmaceutically relevant compoundlibraries. This platform allows for enhanced material efficiency, as reactionscan be performed on picomole scale. Furthermore, high-throughput datacollection via on-line ESI mass spectrometry facilitates the rapid ana[1]lysisof individual, nanoliter-sized reaction droplets at acquisition rates of 0.3samples/s. We envision this high-throughput screening platform to expand uponthe robust capabilities and impact of photochemical reactions in drug discoveryand development.

图 1：光化学液滴微流控平台的开发。EIC 提取离子色谱图，ESI-MS 电喷雾离子化质谱仪。

图 2：液滴内三氟甲基化反应的 ESI-MS 分析。

图 3：利用液滴微流控技术发现皮摩尔尺度的 HTE 反应。

图 4：用于添加试剂的微流控芯片。

A droplet microfluidic platform for high-throughputphotochemical reaction discovery